Clump MR object exposure

Clump MR object exposure

clump_mr(
  x,
  p1 = 1,
  p2 = 1,
  r2 = 0.001,
  kb = 250,
  plink2 = genepi.utils::which_plink2(),
  plink_ref = genepi.utils::which_1000G_reference(build = "GRCh37"),
  parallel_cores = parallel::detectCores()
)

Arguments

x

an object of class MR description

p1

a numeric, the p-value threshold for inclusion as a clump

p2

a numeric, the p-value threshold for incorporation into a clump

r2

a numeric, the r2 value

kb

a integer, the window for clumping

plink2

a string, path to the plink executable

plink_ref

a string, path to the pfile genome reference

parallel_cores

an integer, how many cores / threads to use