Clump MR object exposure

Usage

clump_mr(
  x,
  p1 = 1,
  p2 = 1,
  r2 = 0.001,
  kb = 250,
  plink2 = genepi.utils::which_plink2(),
  plink_ref = genepi.utils::which_1000G_reference(build = "GRCh37"),
  parallel_cores = parallel::detectCores()
)

Arguments

x: an object of class MR description
p1: a numeric, the p-value threshold for inclusion as a clump
p2: a numeric, the p-value threshold for incorporation into a clump
r2: a numeric, the r2 value
kb: a integer, the window for clumping
plink2: a string, path to the plink executable
plink_ref: a string, path to the pfile genome reference
parallel_cores: an integer, how many cores / threads to use