GWAS standardisation

Functions for standardising GWAS inputs

GWAS()

GWAS object

ColumnMap()

ColumnMap object

Column()

Column object

lift()

Liftover GWAS positions

as.data.table()

as.data.table

GWAS processing

Functions for prosessing GWAS data

clump()

Clump a GWAS

harmonise()

Harmonise GWAS effects

ld_matrix()

Calculate LD matrix

get_pfile_variants()

Extract variants from plink binary

get_proxies()

Get proxies for variants from plink binary

subset_gwas()

subset_gwas

Mendelian Randomization

Functions for performing MR

MR()

MR object

reset_index_snp()

Reset index SNP

clump_mr()

Clump MR object exposure

mr_egger()

Run Egger MR

mr_ivw()

Run IVW MR

mr_pcgmm()

Run PC-GMM MR

mr_results_to_data_table()

MR results to data.table

mr_weighted_median()

Run weighted median MR

mr_weighted_mode()

Run weighted mode MR

run_mr()

Run MR

plot_mr()

Plot MR results

set_ld_mat()

Set the LD matrix

to_MRInput()

Convert to MendelianRandomization::MRInput object

to_MRMVInput()

Convert to MendelianRandomization::MRMVInput object

ld_matrix()

Calculate LD matrix

RSID mapping

Functions for mapping chromosome and position data to variant RSIDs

chrpos_to_rsid()

Chromosome & position data to variant RSID

Collider bias

Functions for analysing collider / index event bias and adjust GWAS data for this bias.

collider_bias()

Run collider bias assessment

cwls()

Corrected Weighted Least Squares collider bias method

slopehunter()

Slope-Hunter collider bias method

dudbridge()

Dudbridge collider bias method

Plotting

Functions for creating common GenEpi data plots

manhattan()

Manhattan plot

miami()

Miami plot

qq_plot()

QQ plot

eaf_plot()

Effect allele frequency plot

generate_random_gwas_data()

Generate random GWAS data

plot_coloc_probabilities()

Coloc probability plot

Setup

Functions for package configuration

set_dbsnp_directory()

Set dbSNP directory

which_dbsnp_builds()

Get available dbSNP builds

which_dbsnp_directory()

Get dbSNP directory

set_1000G_reference()

Set the 1000G reference path

set_plink2()

Set the PLINK2 path

which_1000G_reference()

Get 1000G reference path(s)

which_plink2()

Get plink2 path